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T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) is recruited to the immune synapse, disrupts stable synapse formation and associates with receptor phosphatases
CD8(+) cytotoxic T lymphocytes (CTL) are adept at killing virally infected cells and cancer cells and releasing cytokines (e.g. IFN-γ) to aid this response. However, during cancer and chronic viral infections, such as with Human Immunodeficiency Virus, this CTL response is progressively impaired due...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4214929/ https://ncbi.nlm.nih.gov/pubmed/24337741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302663 |
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