Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin

The bone microenvironment is composed of niches that house cells across variable oxygen tensions. However, the contribution of oxygen gradients in regulating bone and blood homeostasis remains unknown. Here, we generated mice with either single or combined genetic inactivation of the critical oxygen...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Wu, Colleen, Rankin, Erinn B., Castellini, Laura, Fernandez-Alcudia, Javier, LaGory, Edward L., Andersen, Rebecca, Rhodes, Steven D., Wilson, Tremika L.S., Mohammad, Khalid S., Castillo, Alesha B., Guise, Theresa A., Schipani, Ernestina, Giaccia, Amato J.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403258/
https://ncbi.nlm.nih.gov/pubmed/25846796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.255000.114
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