Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin

The bone microenvironment is composed of niches that house cells across variable oxygen tensions. However, the contribution of oxygen gradients in regulating bone and blood homeostasis remains unknown. Here, we generated mice with either single or combined genetic inactivation of the critical oxygen...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Wu, Colleen, Rankin, Erinn B., Castellini, Laura, Fernandez-Alcudia, Javier, LaGory, Edward L., Andersen, Rebecca, Rhodes, Steven D., Wilson, Tremika L.S., Mohammad, Khalid S., Castillo, Alesha B., Guise, Theresa A., Schipani, Ernestina, Giaccia, Amato J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403258/
https://ncbi.nlm.nih.gov/pubmed/25846796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.255000.114
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