Autoinhibition of MDMX by intramolecular p53 mimicry

The p53 inhibitor MDMX is controlled by multiple stress signaling pathways. Using a proteolytic fragment release (PFR) assay, we detected an intramolecular interaction in MDMX that mechanistically mimics the interaction with p53, resulting in autoinhibition of MDMX. This mimicry is mediated by a hyd...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Chen, Lihong, Borcherds, Wade, Wu, Shaofang, Becker, Andreas, Schonbrunn, Ernst, Daughdrill, Gary W., Chen, Jiandong
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403185/
https://ncbi.nlm.nih.gov/pubmed/25825738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420833112
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