Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells

NANOG (from Irish mythology Tír na nÓg) transcription factor plays a central role in maintaining pluripotency, cooperating with OCT4 (also known as POU5F1 or OCT3/4), SOX2, and other pluripotency factors. Although the physiological roles of the NANOG protein have been extensively explored, biochemic...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Hayashi, Yohei, Caboni, Laura, Das, Debanu, Yumoto, Fumiaki, Clayton, Thomas, Deller, Marc C., Nguyen, Phuong, Farr, Carol L., Chiu, Hsiu-Ju, Miller, Mitchell D., Elsliger, Marc-André, Deacon, Ashley M., Godzik, Adam, Lesley, Scott A., Tomoda, Kiichiro, Conklin, Bruce R., Wilson, Ian A., Yamanaka, Shinya, Fletterick, Robert J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403148/
https://ncbi.nlm.nih.gov/pubmed/25825768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502855112
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