PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression

Enhancer of zeste homolog 2 (EZH2) is a key epigenetic regulator that catalyzes the trimethylation of H3K27 and is modulated by post-translational modifications (PTMs). However, the precise regulation of EZH2 PTMs remains elusive. We, herein, report that EZH2 is acetylated by acetyltransferase P300/...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Wan, Junhu, Zhan, Jun, Li, Shuai, Ma, Ji, Xu, Weizhi, Liu, Chang, Xue, Xiaowei, Xie, Yuping, Fang, Weigang, Chin, Y. Eugene, Zhang, Hongquan
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Gene regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402543/
https://ncbi.nlm.nih.gov/pubmed/25800736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv238
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