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Efficient CRISPR-rAAV engineering of endogenous genes to study protein function by allele-specific RNAi
Gene knockout strategies, RNAi and rescue experiments are all employed to study mammalian gene function. However, the disadvantages of these approaches include: loss of function adaptation, reduced viability and gene overexpression that rarely matches endogenous levels. Here, we developed an endogen...
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| Publicat a: | Nucleic Acids Res |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4402508/ https://ncbi.nlm.nih.gov/pubmed/25586224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1403 |
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