Acquisition of relative interstrand crosslinker resistance and PARP inhibitor sensitivity in Fanconi anemia head and neck cancers

PURPOSE: Fanconi anemia (FA) is an inherited disorder associated with a constitutional defect in the FA DNA repair machinery that is essential for resolution of DNA interstrand crosslinks. Individuals with FA are predisposed to formation of head and neck squamous cell carcinomas (HNSCCs) at a young...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Clin Cancer Res
Prif Awduron: Lombardi, Anne J., Hoskins, Elizabeth E., Foglesong, Grant D., Wikenheiser-Brokamp, Kathryn A., Wiesmüller, Lisa, Hanenberg, Helmut, Andreassen, Paul R., Jacobs, Allison J., Olson, Susan B., Keeble, Winifred W., Hays, Laura E., Wells, Susanne I.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401632/
https://ncbi.nlm.nih.gov/pubmed/25609062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2616
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