Acquisition of relative interstrand crosslinker resistance and PARP inhibitor sensitivity in Fanconi anemia head and neck cancers

PURPOSE: Fanconi anemia (FA) is an inherited disorder associated with a constitutional defect in the FA DNA repair machinery that is essential for resolution of DNA interstrand crosslinks. Individuals with FA are predisposed to formation of head and neck squamous cell carcinomas (HNSCCs) at a young...

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Publicado en:Clin Cancer Res
Autores principales: Lombardi, Anne J., Hoskins, Elizabeth E., Foglesong, Grant D., Wikenheiser-Brokamp, Kathryn A., Wiesmüller, Lisa, Hanenberg, Helmut, Andreassen, Paul R., Jacobs, Allison J., Olson, Susan B., Keeble, Winifred W., Hays, Laura E., Wells, Susanne I.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401632/
https://ncbi.nlm.nih.gov/pubmed/25609062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2616
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