Acquisition of relative interstrand crosslinker resistance and PARP inhibitor sensitivity in Fanconi anemia head and neck cancers

PURPOSE: Fanconi anemia (FA) is an inherited disorder associated with a constitutional defect in the FA DNA repair machinery that is essential for resolution of DNA interstrand crosslinks. Individuals with FA are predisposed to formation of head and neck squamous cell carcinomas (HNSCCs) at a young...

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Publicado no:Clin Cancer Res
Main Authors: Lombardi, Anne J., Hoskins, Elizabeth E., Foglesong, Grant D., Wikenheiser-Brokamp, Kathryn A., Wiesmüller, Lisa, Hanenberg, Helmut, Andreassen, Paul R., Jacobs, Allison J., Olson, Susan B., Keeble, Winifred W., Hays, Laura E., Wells, Susanne I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401632/
https://ncbi.nlm.nih.gov/pubmed/25609062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2616
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