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Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE,in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease

Oxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD). Both AD and arguably its earlier form, mild cognitive impairment (MCI), have elevated membrane oxidative damage in brain. The tumor suppressor and transcription factor p53 plays a pivotal function in neuronal...

詳細記述

保存先:
書誌詳細
出版年:J Cell Mol Med
主要な著者: Cenini, Giovanna, Sultana, Rukhsana, Memo, Maurizio, Butterfield, D Allan
フォーマット: Artigo
言語:Inglês
出版事項: Blackwell Publishing Ltd 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401131/
https://ncbi.nlm.nih.gov/pubmed/18494939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2008.00163.x
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