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Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE,in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease

Oxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD). Both AD and arguably its earlier form, mild cognitive impairment (MCI), have elevated membrane oxidative damage in brain. The tumor suppressor and transcription factor p53 plays a pivotal function in neuronal...

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Bibliografiske detaljer
Udgivet i:J Cell Mol Med
Main Authors: Cenini, Giovanna, Sultana, Rukhsana, Memo, Maurizio, Butterfield, D Allan
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401131/
https://ncbi.nlm.nih.gov/pubmed/18494939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2008.00163.x
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