The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

Abnormal activation of insulin-like growth factor (IGF)-Akt signaling is implicated in the development of various diseases, including heart failure. However, the molecular mechanisms that regulate activation of this signaling pathway are not completely understood. Here we show that sirtuin 6 (SIRT6)...

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Pubblicato in:Nat Med
Autori principali: Sundaresan, Nagalingam R, Vasudevan, Prabhakaran, Zhong, Lei, Kim, Gene, Samant, Sadhana, Parekh, Vishwas, Pillai, Vinodkumar B, Ravindra, P V, Gupta, Madhu, Jeevanandam, Valluvan, Cunningham, John M, Deng, Chu-Xia, Lombard, David B, Mostoslavsky, Raul, Gupta, Mahesh P
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401084/
https://ncbi.nlm.nih.gov/pubmed/23086477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2961
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