Modeling the Early Phenotype at the Neuromuscular Junction of Spinal Muscular Atrophy Using Patient-Derived iPSCs

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by mutations of the survival of motor neuron 1 (SMN1) gene. In the pathogenesis of SMA, pathological changes of the neuromuscular junction (NMJ) precede the motor neuronal loss. Therefore, it is critical to evaluate the NMJ formed by S...

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Foilsithe in:Stem Cell Reports
Main Authors: Yoshida, Michiko, Kitaoka, Shiho, Egawa, Naohiro, Yamane, Mayu, Ikeda, Ryunosuke, Tsukita, Kayoko, Amano, Naoki, Watanabe, Akira, Morimoto, Masafumi, Takahashi, Jun, Hosoi, Hajime, Nakahata, Tatsutoshi, Inoue, Haruhisa, Saito, Megumu K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2015
Ábhair:
Report
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400613/
https://ncbi.nlm.nih.gov/pubmed/25801509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.02.010
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