Proteasome impairment in neural cells derived from HMSN-P patient iPSCs

Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) is caused by a heterozygous mutation (P285L) in Tropomyosin-receptor kinase Fused Gene (TFG), histopathologically characterized by progressive spinal motor neuron loss with TFG cytosolic aggregates. Although the TFG...

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Dettagli Bibliografici
Pubblicato in:Mol Brain
Autori principali: Murakami, Nagahisa, Imamura, Keiko, Izumi, Yuishin, Egawa, Naohiro, Tsukita, Kayoko, Enami, Takako, Yamamoto, Takuya, Kawarai, Toshitaka, Kaji, Ryuji, Inoue, Haruhisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5310050/
https://ncbi.nlm.nih.gov/pubmed/28196470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-017-0286-y
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