Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes

Alexander disease is a fatal neurological illness characterized by white-matter degeneration and formation of Rosenthal fibers, which contain glial fibrillary acidic protein as astrocytic inclusion. Alexander disease is mainly caused by a gene mutation encoding glial fibrillary acidic protein, altho...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Kondo, Takayuki, Funayama, Misato, Miyake, Michiyo, Tsukita, Kayoko, Era, Takumi, Osaka, Hitoshi, Ayaki, Takashi, Takahashi, Ryosuke, Inoue, Haruhisa
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940830/
https://ncbi.nlm.nih.gov/pubmed/27402089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0337-0
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