17ß-Estradiol Regulates mTORC2 Sensitivity to Rapamycin in Adaptive Cardiac Remodeling

Adaptive cardiac remodeling is characterized by enhanced signaling of mTORC2 downstream kinase Akt. In females, 17ß-estradiol (E2), as well as Akt contribute essentially to sex-related premenopausal cardioprotection. Pharmacologic mTOR targeting with rapamycin is increasingly used for various clinic...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Kusch, Angelika, Schmidt, Maria, Gürgen, Dennis, Postpieszala, Daniel, Catar, Rusan, Hegner, Björn, Davidson, Merci M., Mahmoodzadeh, Shokoufeh, Dragun, Duska
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399939/
https://ncbi.nlm.nih.gov/pubmed/25880554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123385
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы