17ß-Estradiol Regulates mTORC2 Sensitivity to Rapamycin in Adaptive Cardiac Remodeling

Adaptive cardiac remodeling is characterized by enhanced signaling of mTORC2 downstream kinase Akt. In females, 17ß-estradiol (E2), as well as Akt contribute essentially to sex-related premenopausal cardioprotection. Pharmacologic mTOR targeting with rapamycin is increasingly used for various clinic...

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Udgivet i:PLoS One
Main Authors: Kusch, Angelika, Schmidt, Maria, Gürgen, Dennis, Postpieszala, Daniel, Catar, Rusan, Hegner, Björn, Davidson, Merci M., Mahmoodzadeh, Shokoufeh, Dragun, Duska
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399939/
https://ncbi.nlm.nih.gov/pubmed/25880554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123385
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