Intrinsic Deregulation of Vascular Smooth Muscle and Myofibroblast Differentiation in Mesenchymal Stromal Cells from Patients with Systemic Sclerosis

INTRODUCTION: Obliterative vasculopathy and fibrosis are hallmarks of systemic sclerosis (SSc), a severe systemic autoimmune disease. Bone marrow-derived mesenchymal stromal cells (MSCs) from SSc patients may harbor disease-specific abnormalities. We hypothesized disturbed vascular smooth muscle cel...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hegner, Björn, Schaub, Theres, Catar, Rusan, Kusch, Angelika, Wagner, Philine, Essin, Kirill, Lange, Claudia, Riemekasten, Gabriela, Dragun, Duska
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824407/
https://ncbi.nlm.nih.gov/pubmed/27054717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153101
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