Human GM3 Synthase Attenuates Taxol-Triggered Apoptosis Associated with Downregulation of Caspase-3 in Ovarian Cancer Cells

BACKGROUND: Taxol (paclitaxel) inhibits proliferation and induces apoptosis in a variety of cancer cells, but it also upregulates cytoprotective proteins and/or pathways that compromise its therapeutic efficacy. MATERIALS AND METHOD: The roles of GM3 synthase (α2,3-sialyltransferase, ST3Gal V) in at...

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I publikationen:J Cancer Ther
Huvudupphovsmän: Huang, Su, Bijangi-Vishehsaraei, Khadijeh, Saadatzadeh, Mohammad Reza, Safa, Ahmad R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399708/
https://ncbi.nlm.nih.gov/pubmed/25893133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4236/jct.2012.35065
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