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4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells

Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a major resistance factor for the tumor necrosis factor-related apoptosis-inducing ligand TRAIL and in drug resistance in human malignancies. c-FLIP is an antagonist of caspases-8 and -10, which inhibits apoptosis and...

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Detalhes bibliográficos
Publicado no:Mol Cell Biochem
Main Authors: Bijangi-Vishehsaraei, Khadijeh, Huang, Su, Safa, Ahmad R., Saadatzadeh, Mohammad Reza, Murphy, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450253/
https://ncbi.nlm.nih.gov/pubmed/20446019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-010-0477-7
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