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ADP-ribose/TRPM2-mediated Ca(2+) signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells
Natural killer (NK) cells are essential for immunosurveillance against transformed cells. Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel gated by ADP-ribose (ADPR). However, the role of TRPM2-mediated Ca(2+) signaling in the antitumor response of NK cells has...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4399500/ https://ncbi.nlm.nih.gov/pubmed/25879940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09482 |
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