ADP-ribose/TRPM2-mediated Ca(2+) signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells

Natural killer (NK) cells are essential for immunosurveillance against transformed cells. Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel gated by ADP-ribose (ADPR). However, the role of TRPM2-mediated Ca(2+) signaling in the antitumor response of NK cells has...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Rah, So-Young, Kwak, Jae-Yong, Chung, Yun-Jo, Kim, Uh-Hyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399500/
https://ncbi.nlm.nih.gov/pubmed/25879940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09482
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