Excessive Growth Hormone Expression in Male GH Transgenic Mice Adversely Alters Bone Architecture and Mechanical Strength

Patients with acromegaly have a higher prevalence of vertebral fractures despite normal bone mineral density (BMD), suggesting that GH overexpression has adverse effects on skeletal architecture and strength. We used giant bovine GH (bGH) transgenic mice to analyze the effects of high serum GH level...

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Bibliographic Details
Published in:Endocrinology
Main Authors: Lim, S. V., Marenzana, M., Hopkinson, M., List, E. O., Kopchick, J. J., Pereira, M., Javaheri, B., Roux, J. P., Chavassieux, P., Korbonits, M., Chenu, C.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2015
Subjects:
Growth Hormone-Somatostatin-GRH
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399323/
https://ncbi.nlm.nih.gov/pubmed/25646711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1572
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