Excessive Growth Hormone Expression in Male GH Transgenic Mice Adversely Alters Bone Architecture and Mechanical Strength

Patients with acromegaly have a higher prevalence of vertebral fractures despite normal bone mineral density (BMD), suggesting that GH overexpression has adverse effects on skeletal architecture and strength. We used giant bovine GH (bGH) transgenic mice to analyze the effects of high serum GH level...

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Detalles Bibliográficos
Publicado en:Endocrinology
Autores principales: Lim, S. V., Marenzana, M., Hopkinson, M., List, E. O., Kopchick, J. J., Pereira, M., Javaheri, B., Roux, J. P., Chavassieux, P., Korbonits, M., Chenu, C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2015
Materias:
Growth Hormone-Somatostatin-GRH
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399323/
https://ncbi.nlm.nih.gov/pubmed/25646711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1572
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