Excessive Growth Hormone Expression in Male GH Transgenic Mice Adversely Alters Bone Architecture and Mechanical Strength

Patients with acromegaly have a higher prevalence of vertebral fractures despite normal bone mineral density (BMD), suggesting that GH overexpression has adverse effects on skeletal architecture and strength. We used giant bovine GH (bGH) transgenic mice to analyze the effects of high serum GH level...

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Udgivet i:Endocrinology
Main Authors: Lim, S. V., Marenzana, M., Hopkinson, M., List, E. O., Kopchick, J. J., Pereira, M., Javaheri, B., Roux, J. P., Chavassieux, P., Korbonits, M., Chenu, C.
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2015
Fag:
Growth Hormone-Somatostatin-GRH
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399323/
https://ncbi.nlm.nih.gov/pubmed/25646711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1572
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