Growth Hormone Receptor Antagonist Transgenic Mice Are Protected From Hyperinsulinemia and Glucose Intolerance Despite Obesity When Placed on a HF Diet

Reduced GH levels have been associated with improved glucose metabolism and increased longevity despite obesity in multiple mouse lines. However, one mouse line, the GH receptor antagonist (GHA) transgenic mouse, defies this trend because it has reduced GH action and increased adiposity, but glucose...

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Publicado en:Endocrinology
Autores principales: Yang, Tianxu, Householder, Lara A., Lubbers, Ellen R., List, Edward O., Troike, Katie, Vesel, Clare, Duran-Ortiz, Silvana, Kopchick, John J., Berryman, Darlene E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2015
Materias:
Growth Hormone-Somatostatin-GRH
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298328/
https://ncbi.nlm.nih.gov/pubmed/25406017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1617
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