Growth Hormone Receptor Antagonist Transgenic Mice Are Protected From Hyperinsulinemia and Glucose Intolerance Despite Obesity When Placed on a HF Diet

Reduced GH levels have been associated with improved glucose metabolism and increased longevity despite obesity in multiple mouse lines. However, one mouse line, the GH receptor antagonist (GHA) transgenic mouse, defies this trend because it has reduced GH action and increased adiposity, but glucose...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Yang, Tianxu, Householder, Lara A., Lubbers, Ellen R., List, Edward O., Troike, Katie, Vesel, Clare, Duran-Ortiz, Silvana, Kopchick, John J., Berryman, Darlene E.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
Assuntos:
Growth Hormone-Somatostatin-GRH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298328/
https://ncbi.nlm.nih.gov/pubmed/25406017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1617
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