RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals

CONTEXT: Activation of the melanocortin-4 receptor (MC4R) with the synthetic agonist RM-493 decreases body weight and increases energy expenditure (EE) in nonhuman primates. The effects of MC4R agonists on EE in humans have not been examined to date. OBJECTIVE, DESIGN, AND SETTING: In a randomized,...

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Publicado no:J Clin Endocrinol Metab
Main Authors: Chen, Kong Y., Muniyappa, Ranganath, Abel, Brent S., Mullins, Katherine P., Staker, Pamela, Brychta, Robert J., Zhao, Xiongce, Ring, Michael, Psota, Tricia L., Cone, Roger D., Panaro, Brandon L., Gottesdiener, Keith M., Van der Ploeg, Lex H.T., Reitman, Marc L., Skarulis, Monica C.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399297/
https://ncbi.nlm.nih.gov/pubmed/25675384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2014-4024
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