Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice

We assessed the efficacy of simultaneous agonism at the glucagon-like peptide-1 receptor (GLP-1R) and the melanocortin-4 receptor (MC4R) for the treatment of obesity and diabetes in rodents. Diet-induced obese (DIO) mice were chronically treated with either the long-acting GLP-1R agonist liraglutide...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Clemmensen, Christoffer, Finan, Brian, Fischer, Katrin, Tom, Robby Zachariah, Legutko, Beata, Sehrer, Laura, Heine, Daniela, Grassl, Niklas, Meyer, Carola W, Henderson, Bart, Hofmann, Susanna M, Tschöp, Matthias H, Van der Ploeg, Lex HT, Müller, Timo D
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364946/
https://ncbi.nlm.nih.gov/pubmed/25652173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404508
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