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Melanocortin-4 receptor mutations paradoxically reduce preference for palatable foods
Haploinsufficiency of the melanocortin-4 receptor (MC4R) results in melanocortin obesity syndrome, the most common monogenic cause of severe early onset obesity in humans. The syndrome, which produces measurable hyperphagia, has focused attention on the role of MC4R in feeding behavior and macronutr...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3637712/ https://ncbi.nlm.nih.gov/pubmed/23569235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304707110 |
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