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Biochemical, biological and structural properties of romidepsin (FK228) and its analogs as novel HDAC/PI3K dual inhibitors

Romidepsin (FK228, depsipeptide) is a potent histone deacetylase (HDAC) inhibitor that has FDA approval for the treatment of cutaneous and peripheral T-cell lymphomas. We have previously reported that FK228 and its analogs have an additional activity as phosphatidylinositol 3-kinase (PI3K) inhibitor...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Saijo, Ken, Imamura, Jin, Narita, Koichi, Oda, Akifumi, Shimodaira, Hideki, Katoh, Tadashi, Ishioka, Chikashi
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399029/
https://ncbi.nlm.nih.gov/pubmed/25492515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12585
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