Metformin suppresses pancreatic tumor growth with inhibition of NFκB/STAT3 inflammatory signaling

OBJECTIVES: To further elucidate anti-cancer mechanisms of metformin again pancreatic cancer, we evaluated inhibitory effects of metformin on pancreatic tumorigenesis in a genetically-engineered mouse model, and investigated its possible anti-inflammatory and anti-angiogenesis effects. METHODS: Six-...

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Detalhes bibliográficos
Publicado no:Pancreas
Main Authors: Tan, Xiang-Lin, Bhattacharyya, Kalyan K., Dutta, Shamit K., Bamlet, William R., Rabe, Kari G., Wang, Enfeng, Smyrk, Thomas C., Oberg, Ann L., Petersen, Gloria M., Mukhopadhyay, Debabrata
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399019/
https://ncbi.nlm.nih.gov/pubmed/25875801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0000000000000308
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