Pancreatic Cancer-derived Exosomes Causes Paraneoplastic β-cell Dysfunction

BACKGROUND & AIMS: Pancreatic cancer (PC) frequently causes diabetes. We recently proposed adrenomedullin (AM) as a candidate mediator of pancreatic β-cell dysfunction in PC. How PC-derived AM reaches β-cells remote from the cancer to induce β-cell dysfunction is unknown. We tested a novel hypot...

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Bibliografiska uppgifter
I publikationen:Clin Cancer Res
Huvudupphovsmän: Javeed, Naureen, Sagar, Gunisha, Dutta, Shamit K., Smyrk, Thomas C., Lau, Julie S., Bhattacharya, Santanu, Truty, Mark, Petersen, Gloria M., Kaufman, Randal J., Chari, Suresh T., Mukhopadhyay, Debabrata
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383684/
https://ncbi.nlm.nih.gov/pubmed/25355928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2022
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