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Inhibitor-κB kinase attenuates Hsp90-dependent endothelial nitric oxide synthase function in vascular endothelial cells

Endothelial nitric oxide (NO) synthase (eNOS) is the predominant isoform that generates NO in the blood vessels. Many different regulators, including heat shock protein 90 (Hsp90), govern eNOS function. Hsp90-dependent phosphorylation of eNOS is a critical event that determines eNOS activity. In our...

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Publicat a:Am J Physiol Cell Physiol
Autors principals: Natarajan, Mohan, Konopinski, Ryszard, Krishnan, Manickam, Roman, Linda, Bera, Alakesh, Hongying, Zheng, Habib, Samy L., Mohan, Sumathy
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398846/
https://ncbi.nlm.nih.gov/pubmed/25652452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00367.2014
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