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Inhibitor-κB kinase attenuates Hsp90-dependent endothelial nitric oxide synthase function in vascular endothelial cells

Endothelial nitric oxide (NO) synthase (eNOS) is the predominant isoform that generates NO in the blood vessels. Many different regulators, including heat shock protein 90 (Hsp90), govern eNOS function. Hsp90-dependent phosphorylation of eNOS is a critical event that determines eNOS activity. In our...

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Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Natarajan, Mohan, Konopinski, Ryszard, Krishnan, Manickam, Roman, Linda, Bera, Alakesh, Hongying, Zheng, Habib, Samy L., Mohan, Sumathy
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398846/
https://ncbi.nlm.nih.gov/pubmed/25652452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00367.2014
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