Functional Role of HSP90 Complexes with Endothelial Nitric-oxide Synthase (eNOS) and Calpain on Nitric Oxide Generation in Endothelial Cells

Although several reports have indicated that eNOS is a highly sensitive calpain substrate, the occurrence of a concomitant Ca(2+)-dependent activation of the synthase and of the protease has never been analyzed in specific direct experiments. In this study, we have explored in vivo how eNOS can unde...

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Autors principals: Averna, Monica, Stifanese, Roberto, De Tullio, Roberta, Passalacqua, Mario, Salamino, Franca, Pontremoli, Sandro, Melloni, Edon
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Protein Synthesis, Post-Translational Modification, and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662009/
https://ncbi.nlm.nih.gov/pubmed/18682401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803638200
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