Interaction between Calpain-1 and HSP90: New Insights into the Regulation of Localization and Activity of the Protease

Here we demonstrate that heat shock protein 90 (HSP90) interacts with calpain-1, but not with calpain-2, and forms a discrete complex in which the protease maintains its catalytic activity, although with a lower affinity for Ca(2+). Equilibrium gel distribution experiments show that this complex is...

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Bibliographic Details
Published in:PLoS One
Main Authors: Averna, Monica, De Tullio, Roberta, Pedrazzi, Marco, Bavestrello, Margherita, Pellegrini, Matteo, Salamino, Franca, Pontremoli, Sandro, Melloni, Edon
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289065/
https://ncbi.nlm.nih.gov/pubmed/25575026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116738
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