Calpain Inhibition Promotes the Rescue of F(508)del-CFTR in PBMC from Cystic Fibrosis Patients

A basal calpain activity promotes the limited proteolysis of wild type (WT) cystic fibrosis conductance regulator (CFTR), inducing the internalization of the split channel. This process contributes to the regulation in the level of the active CFTR at the plasma membranes. In peripheral blood mononuc...

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Main Authors: Averna, Monica, Pedrazzi, Marco, Minicucci, Laura, De Tullio, Roberta, Cresta, Federico, Salamino, Franca, Pontremoli, Sandro, Melloni, Edon
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681946/
https://ncbi.nlm.nih.gov/pubmed/23785472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066089
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