Calpain Inhibition Promotes the Rescue of F(508)del-CFTR in PBMC from Cystic Fibrosis Patients

A basal calpain activity promotes the limited proteolysis of wild type (WT) cystic fibrosis conductance regulator (CFTR), inducing the internalization of the split channel. This process contributes to the regulation in the level of the active CFTR at the plasma membranes. In peripheral blood mononuc...

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Detalhes bibliográficos
Main Authors: Averna, Monica, Pedrazzi, Marco, Minicucci, Laura, De Tullio, Roberta, Cresta, Federico, Salamino, Franca, Pontremoli, Sandro, Melloni, Edon
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681946/
https://ncbi.nlm.nih.gov/pubmed/23785472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066089
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