Calpain Inhibition Promotes the Rescue of F(508)del-CFTR in PBMC from Cystic Fibrosis Patients

A basal calpain activity promotes the limited proteolysis of wild type (WT) cystic fibrosis conductance regulator (CFTR), inducing the internalization of the split channel. This process contributes to the regulation in the level of the active CFTR at the plasma membranes. In peripheral blood mononuc...

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Main Authors: Averna, Monica, Pedrazzi, Marco, Minicucci, Laura, De Tullio, Roberta, Cresta, Federico, Salamino, Franca, Pontremoli, Sandro, Melloni, Edon
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681946/
https://ncbi.nlm.nih.gov/pubmed/23785472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066089
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