High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction

A decline in the bioavailability of nitric oxide (NO) that causes endothelial dysfunction is a hallmark of diabetes. The availability of NO to the vasculature is regulated by endothelial nitric oxide synthase (eNOS) activity and the involvement of heat shock protein-90 (Hsp-90) in the regulation of...

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Bibliographic Details
Main Authors: Mohan, Sumathy, Konopinski, Ryszard, Yan, Bo, Centonze, Victoria E., Natarajan, Mohan
Format: Artigo
Language:Inglês
Published: American Physiological Society 2009
Subjects:
Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636992/
https://ncbi.nlm.nih.gov/pubmed/18945937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00575.2007
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