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Differential Effects of Tyrosine Kinase Inhibitors on Normal and Oncogenic EGFR Signaling and Downstream Effectors

Constitutive activation of epidermal growth factor receptor (EGFR) due to overexpression or mutation in tumor cells leads to dysregulated downstream cellular signaling pathways. Therefore, EGFR as well as its downstream effectors have been identified as important therapeutic targets. The FDA approve...

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Bibliografski detalji
Izdano u:Mol Cancer Res
Glavni autori: Kim, Youngjoo, Apetri, Mihaela, Luo, BeiBei, Settleman, Jeffrey E., Anderson, Karen S.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398619/
https://ncbi.nlm.nih.gov/pubmed/25573954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0326
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