BIM Mediates EGFR Tyrosine Kinase Inhibitor-Induced Apoptosis in Lung Cancers with Oncogenic EGFR Mutations

BACKGROUND: Epidermal growth factor receptor (EGFR) mutations are present in the majority of patients with non-small cell lung cancer (NSCLC) responsive to the EGFR tyrosine kinase inhibitors (TKIs) gefitinib or erlotinib. These EGFR-dependent tumors eventually become TKI resistant, and the common s...

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Detalhes bibliográficos
Main Authors: Costa, Daniel B, Halmos, Balázs, Kumar, Amit, Schumer, Susan T, Huberman, Mark S, Boggon, Titus J, Tenen, Daniel G, Kobayashi, Susumu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043012/
https://ncbi.nlm.nih.gov/pubmed/17973572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0040315
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