BRIEF REPORT: Compound EGFR mutations and response to EGFR tyrosine kinase inhibitors

INTRODUCTION: Non-small-cell lung cancers (NSCLCs) containing epidermal growth factor receptor (EGFR) mutations are exquisitely sensitive to EGFR tyrosine kinase inhibitors (TKIs). This is the case of the most common EGFR mutations affecting exon 18 (G719X), 19 (inframe deletions) and 21 (L858R and...

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Detalhes bibliográficos
Main Authors: Kobayashi, Susumu, Canepa, Hannah M., Bailey, Alexandra S., Nakayama, Sohei, Yamaguchi, Norihiro, Goldstein, Michael A., Huberman, Mark S., Costa, Daniel B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531043/
https://ncbi.nlm.nih.gov/pubmed/23242437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e3182781e35
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