Radioprotection of the Brain White Matter by Mn(III) N-Butoxyethylpyridylporphyrin-Based Superoxide Dismutase Mimic MnTnBuOE-2-PyP(5+)

Cranial irradiation is a standard therapy for primary and metastatic brain tumors. A major drawback of radiotherapy (RT), however, is long-term cognitive loss that affects quality of life. Radiation-induced oxidative stress in normal brain tissue is thought to contribute to cognitive decline. We eva...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Weitzel, Douglas H., Tovmasyan, Artak, Ashcraft, Kathleen A., Rajic, Zrinka, Weitner, Tin, Liu, Chunlei, Li, Wei, Buckley, Anne F., Prasad, Mark R., Young, Kenneth H., Rodriguiz, Ramona M., Wetsel, William C., Peters, Katherine B., Spasojevic, Ivan, Herndon, James E., Batinic-Haberle, Ines, Dewhirst, Mark W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397941/
https://ncbi.nlm.nih.gov/pubmed/25319393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0343
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