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The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD
Using transgenic animals harboring a targeted LacZ insertion, we studied the expression pattern of the C9ORF72 mouse ortholog. Unlike most genes mutated in ALS, which are ubiquitously expressed, the C9ORF72-ortholog was most highly transcribed in the neuronal populations sensitive to degeneration in...
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| Publicado en: | Nat Neurosci |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4397902/ https://ncbi.nlm.nih.gov/pubmed/24185425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3566 |
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