Epsin is required for Dishevelled stability and Wnt signaling activation in colon cancer development

Uncontrolled canonical Wnt signaling supports colon epithelial tumor expansion and malignant transformation. Understanding the regulatory mechanisms involved is crucial for elucidating the pathogenesis of and will provide new therapeutic targets for colon cancer. Epsins are ubiquitin-binding adaptor...

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Publicat a:Nat Commun
Autors principals: Chang, Baojun, Tessneer, Kandice L., McManus, John, Liu, Xiaolei, Hahn, Scott, Pasula, Satish, Wu, Hao, Song, Hoogeun, Chen, Yiyuan, Cai, Xiaofeng, Dong, Yunzhou, Brophy, Megan L., Rahman, Ruby, Ma, Jian-Xing, Xia, Lijun, Chen, Hong
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397653/
https://ncbi.nlm.nih.gov/pubmed/25871009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7380
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