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Elucidation of the protonation states of the catalytic residues in mtKasA - Implications for inhibitor design
KasA (β-Ketoacyl ACP synthase I) is involved in the biosynthetic pathway of mycolic acids, an essential component of the cell wall in Mycobacterium tuberculosis. It was shown that KasA is essential for the survival of the pathogen and thus could serve as a new drug target to treat tuberculosis. The...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4397578/ https://ncbi.nlm.nih.gov/pubmed/21615093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200006t |
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