Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring

BACKGROUND: The prevalence of some autoimmune diseases is greater in females compared with males, although disease severity is often greater in males. The reason for this sexual dimorphism is unknown, but it may reflect negative selection of Y chromosome-bearing sperm during spermatogenesis or male...

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Foilsithe in:Genome Biol
Main Authors: Case, Laure K, Wall, Emma H, Osmanski, Erin E, Dragon, Julie A, Saligrama, Naresha, Zachary, James F, Lemos, Bernardo, Blankenhorn, Elizabeth P, Teuscher, Cory
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2015
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396973/
https://ncbi.nlm.nih.gov/pubmed/25886764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0591-7
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