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Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring

BACKGROUND: The prevalence of some autoimmune diseases is greater in females compared with males, although disease severity is often greater in males. The reason for this sexual dimorphism is unknown, but it may reflect negative selection of Y chromosome-bearing sperm during spermatogenesis or male...

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Bibliografske podrobnosti
izdano v:Genome Biol
Main Authors: Case, Laure K, Wall, Emma H, Osmanski, Erin E, Dragon, Julie A, Saligrama, Naresha, Zachary, James F, Lemos, Bernardo, Blankenhorn, Elizabeth P, Teuscher, Cory
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396973/
https://ncbi.nlm.nih.gov/pubmed/25886764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0591-7
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