NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms

Activating-mutations in NOD-like receptor (NLR) family, pyrin domain-containing 3 (NLRP3) cause neonatal-onset multisystem inflammatory disease. However, the ontogeny of skeletal anomalies in this disorder is poorly understood. Mice globally expressing the D301N mutation in Nlrp3 (D303N in human) mo...

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Veröffentlicht in:FASEB J
Hauptverfasser: Qu, Chao, Bonar, Sheri L., Hickman-Brecks, Cynthia L., Abu-Amer, Samer, McGeough, Matthew D., Peña, Carla A., Broderick, Lori, Yang, Chang, Grimston, Susan K., Kading, Jacqueline, Abu-Amer, Yousef, Novack, Deborah V., Hoffman, Hal M., Civitelli, Roberto, Mbalaviele, Gabriel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2015
Schlagworte:
Research Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396608/
https://ncbi.nlm.nih.gov/pubmed/25477279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-264804
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