Casein kinase 1α–dependent feedback loop controls autophagy in RAS-driven cancers

Activating mutations in the RAS oncogene are common in cancer but are difficult to therapeutically target. RAS activation promotes autophagy, a highly regulated catabolic process that metabolically buffers cells in response to diverse stresses. Here we report that casein kinase 1α (CK1α), a ubiquito...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Cheong, Jit Kong, Zhang, Fuquan, Chua, Pei Jou, Bay, Boon Huat, Thorburn, Andrew, Virshup, David M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396475/
https://ncbi.nlm.nih.gov/pubmed/25798617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78018
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