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Casein kinase 1α–dependent feedback loop controls autophagy in RAS-driven cancers
Activating mutations in the RAS oncogene are common in cancer but are difficult to therapeutically target. RAS activation promotes autophagy, a highly regulated catabolic process that metabolically buffers cells in response to diverse stresses. Here we report that casein kinase 1α (CK1α), a ubiquito...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4396475/ https://ncbi.nlm.nih.gov/pubmed/25798617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78018 |
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