Casein kinase 1α–dependent feedback loop controls autophagy in RAS-driven cancers

Activating mutations in the RAS oncogene are common in cancer but are difficult to therapeutically target. RAS activation promotes autophagy, a highly regulated catabolic process that metabolically buffers cells in response to diverse stresses. Here we report that casein kinase 1α (CK1α), a ubiquito...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Cheong, Jit Kong, Zhang, Fuquan, Chua, Pei Jou, Bay, Boon Huat, Thorburn, Andrew, Virshup, David M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2015
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396475/
https://ncbi.nlm.nih.gov/pubmed/25798617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78018
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak