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Transcriptional regulation of autophagy in RAS-driven cancers

RAS-driven cancers exhibit variable dependency on autophagy for survival; however, it is not fully understood how. In this issue of the JCI, Cheong and colleagues demonstrate that RAS-dependent elevation of casein kinase 1α (CK1α) negatively regulates autophagy at the level of autophagy gene transcr...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Hovedforfatter: Amaravadi, Ravi K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409024/
https://ncbi.nlm.nih.gov/pubmed/25798614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81504
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