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Comprehensive identification of arginine methylation in primary T cells reveals regulatory roles in cell signalling

The impact of protein arginine methylation on the regulation of immune functions is virtually unknown. Here, we apply a novel method—isomethionine methyl-SILAC—coupled with antibody-mediated arginine-methylated peptide enrichment to identify methylated peptides in human T cells by mass spectrometry....

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Pubblicato in:Nat Commun
Autori principali: Geoghegan, Vincent, Guo, Ailan, Trudgian, David, Thomas, Benjamin, Acuto, Oreste
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396391/
https://ncbi.nlm.nih.gov/pubmed/25849564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7758
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