Placental Transfer of Rilpivirine in an Ex Vivo Human Cotyledon Perfusion Model

Placental transfers of the HIV nonnucleoside reverse transcriptase inhibitor rilpivirine were investigated in 8 term human cotyledons perfused with rilpivirine (400 ng/ml) in the maternal-to-fetal direction. The mean fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 15 to...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Mandelbrot, Laurent, Duro, Dominique, Belissa, Emilie, Peytavin, Gilles
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394829/
https://ncbi.nlm.nih.gov/pubmed/25691637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00075-15
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